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Üsküdar Üniversitesi

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Original Article

The Effect of Memorizing the Quran on Cognitive Functions

Turkish Title : The Effect of Memorizing the Quran on Cognitive Functions

Sirin Sumeyye,Metin Barıs,Tarhan Nevzat
JNBS, 2021, 8(1), p:22-27

DOI : 10.4103/jnbs.jnbs_42_20

Background: Memorizing the Quran is an education continuing from the early periods of Islamic education until today. Although this education started in the past to protect the Quran, nowadays, it is continuing as a tradition. Aims and Objectives: The main purpose of this study is to investigate the effects of memorizing the Quran on certain cognitive functions of individuals. Materials and Methods: The scope of the study is limited to 18 female and 15 male students who have been studying in the 5th, 6th, and 7th grades of Anatolian Imam Preacher Secondary Schools in different districts of İstanbul. After Demographic Information Questionnaire was used, California Verbal Learning Test children’s version, Wechsler Memory Scale revised visual reproduction subtest, Trail Making Test, and Verbal Fluency Test were applied twice to collect data about individuals before and after memorization training. Results: Findings demonstrated that there is a statistically significant difference
in verbal learning, visual learning, attention speed, and phonemic and semantic fluency before and after memorization training. Conclusion: In conclusion, memorizing the Quran has positive impacts on verbal and visual memory, attention processes, and lexical and semantic fluency of individuals. It is important with regard to eliminate emptiness in the literature. In future studies, it can be investigated the effects of textual memorization in a foreign language on brain structures and connections.

Background: Memorizing the Quran is an education continuing from the early periods of Islamic education until today. Although this education started in the past to protect the Quran, nowadays, it is continuing as a tradition. Aims and Objectives: The main purpose of this study is to investigate the effects of memorizing the Quran on certain cognitive functions of individuals. Materials and Methods: The scope of the study is limited to 18 female and 15 male students who have been studying in the 5th, 6th, and 7th grades of Anatolian Imam Preacher Secondary Schools in different districts of İstanbul. After Demographic Information Questionnaire was used, California Verbal Learning Test children’s version, Wechsler Memory Scale revised visual reproduction subtest, Trail Making Test, and Verbal Fluency Test were applied twice to collect data about individuals before and after memorization training. Results: Findings demonstrated that there is a statistically significant difference
in verbal learning, visual learning, attention speed, and phonemic and semantic fluency before and after memorization training. Conclusion: In conclusion, memorizing the Quran has positive impacts on verbal and visual memory, attention processes, and lexical and semantic fluency of individuals. It is important with regard to eliminate emptiness in the literature. In future studies, it can be investigated the effects of textual memorization in a foreign language on brain structures and connections.


Original Article

Comparison and Examination of the Death Anxiety of Parents with and Without Having Mental Retarded Children

Turkish Title : Comparison and Examination of the Death Anxiety of Parents with and Without Having Mental Retarded Children

Demir Gumus Zeynep,Guler Kahraman,Aktan Aner Emel,Sevimli Deniz
JNBS, 2021, 8(1), p:28-35

DOI : 10.4103/jnbs.jnbs_46_20

Aims and Objectives: The aim of this study is to have children with and without mental retardation (MR) (diagnosed with MR), it is to compare and examine parents’ death anxiety. Materials and Methods: The research is based on the screening model. The sample group of the study consists of 120 people in total, consisting of parents (n = 60) of children who are followed up in a private counseling and research center due to the presence of intellectual disability, and parents with typically developed children (n = 60) as the comparison group. Sociodemographic information of the participants, who could be included in the study on a voluntary basis, was filled in by the researcher using face to face interview method using the Sociodemographic Information Form, and their death anxiety levels were evaluated with the Multidimensional Evaluation Inventory for Death and Dying. In comparing the quantitative data of the study, the t test, which is the two independent variable tests, was used to analyze the difference between the two parametric groups. The relationship between the scales was tested with Pearson Correlation analysis. Multiple linear regression was used to see the effect of independent variables on the dependent variable. Results: As a result of the research findings, it was found that there are statistically significant differences (P < 0.05) between the scores of the compared groups. Death anxiety of parents with mentally retarded children was found to be higher than parents of typically developed children. Conclusion: This research is important in terms of providing the opportunity for cross cultural comparison and contributing to the policies to be developed on the subject..

Aims and Objectives: The aim of this study is to have children with and without mental retardation (MR) (diagnosed with MR), it is to compare and examine parents’ death anxiety. Materials and Methods: The research is based on the screening model. The sample group of the study consists of 120 people in total, consisting of parents (n = 60) of children who are followed up in a private counseling and research center due to the presence of intellectual disability, and parents with typically developed children (n = 60) as the comparison group. Sociodemographic information of the participants, who could be included in the study on a voluntary basis, was filled in by the researcher using face to face interview method using the Sociodemographic Information Form, and their death anxiety levels were evaluated with the Multidimensional Evaluation Inventory for Death and Dying. In comparing the quantitative data of the study, the t test, which is the two independent variable tests, was used to analyze the difference between the two parametric groups. The relationship between the scales was tested with Pearson Correlation analysis. Multiple linear regression was used to see the effect of independent variables on the dependent variable. Results: As a result of the research findings, it was found that there are statistically significant differences (P < 0.05) between the scores of the compared groups. Death anxiety of parents with mentally retarded children was found to be higher than parents of typically developed children. Conclusion: This research is important in terms of providing the opportunity for cross cultural comparison and contributing to the policies to be developed on the subject..


Original Article

The Relationship between Obsessive‑Compulsive Symptoms and Religious Attitudes

Turkish Title : The Relationship between Obsessive‑Compulsive Symptoms and Religious Attitudes

Cınar Tayfun,Tan Oğuz,Keskin Remziye,Sayar Hızlı Gokben
JNBS, 2021, 8(1), p:36-41

DOI : 10.4103/jnbs.jnbs_39_20

Objective: This study aimed to examine the relationship between obsessive compulsive symptoms and religious attitudes. Method: A total of 80 people, 40 females and 40 males, randomly selected between the ages of 18 and 65 participated in the study. Participants were given Sociodemographic Information Form, the Padua Inventory, and Ok Religious Attitude Scale. Results: Based on the findings, there was no statistically significant relationship between obsessive compulsive symptoms subscales and religious attitudes. According to results related to sociodemographic variables, no statistically significant difference was found between sociodemographic variables of the participants and obsessive compulsive symptoms. No statistically significant difference was found between the religious attitudes of the participants and their sociodemographic variables. Conclusion: Because the number of study for understanding these variable is limited in Turkey, It can be considered that the findings of the study related to obsessive-compulsive symptoms and religious attitudes is contributive in terms of providing further information for future research.

Objective: This study aimed to examine the relationship between obsessive compulsive symptoms and religious attitudes. Method: A total of 80 people, 40 females and 40 males, randomly selected between the ages of 18 and 65 participated in the study. Participants were given Sociodemographic Information Form, the Padua Inventory, and Ok Religious Attitude Scale. Results: Based on the findings, there was no statistically significant relationship between obsessive compulsive symptoms subscales and religious attitudes. According to results related to sociodemographic variables, no statistically significant difference was found between sociodemographic variables of the participants and obsessive compulsive symptoms. No statistically significant difference was found between the religious attitudes of the participants and their sociodemographic variables. Conclusion: Because the number of study for understanding these variable is limited in Turkey, It can be considered that the findings of the study related to obsessive-compulsive symptoms and religious attitudes is contributive in terms of providing further information for future research.


Original Article

Investigation of Obsessions and Compulsions in Terms of Psychological Resilience in the Epidemic Period

Turkish Title : Investigation of Obsessions and Compulsions in Terms of Psychological Resilience in the Epidemic Period

Atalay Zeynep,Cebi Merve,Demir Gumus Zeynep
JNBS, 2021, 8(1), p:42-53

DOI : 10.4103/jnbs.jnbs_11_21

Aims and Objectives: In this study, obsessions and compulsions observed during the epidemic period were investigated in terms of psychological resilience. Materials and Methods: The research was conducted on a voluntary basis with 208 people (51.4% women, 48.6% men) who were exposed to the COVID 19 epidemic. Participants were given a Sociodemographic Information Form including questions about COVID 19, Vancouver Obsession–Compulsion Inventory (VOCI), and Adult Psychological Resilience Scale. Data were analyzed with Statistical Package Program for Social Science 21.0 program. Results: When the findings were examined, no difference was found between obsession–compulsion and psychological resilience in terms of total score. However, there are relationships in subdimensions. Contamination subscore of VOCI and social resources subscore of Resilience Scale for Adults were found to be higher than the others. Hoarding was higher in men, while self perception, structural style, and family cohesion were higher in women. Single participants
had higher obsession–compulsion scores, whereas married participants had higher self perception and family adjustment. It was concluded that as individuals’ age increased, their self perception and social competence increased. Relationships were also found in terms of both obsession–compulsion and psychological resilience with variables, such as the frequency of COVID 19 news and case follow up, the frequency of body screening for COVID 19 symptoms, the change in the frequency of cleaning, and the idea of getting psychological support. Conclusion: This research is significant when it comes to seeing the effect of a compulsive life event, such as an epidemic disease on obsessive and compulsive behaviors.

Aims and Objectives: In this study, obsessions and compulsions observed during the epidemic period were investigated in terms of psychological resilience. Materials and Methods: The research was conducted on a voluntary basis with 208 people (51.4% women, 48.6% men) who were exposed to the COVID 19 epidemic. Participants were given a Sociodemographic Information Form including questions about COVID 19, Vancouver Obsession–Compulsion Inventory (VOCI), and Adult Psychological Resilience Scale. Data were analyzed with Statistical Package Program for Social Science 21.0 program. Results: When the findings were examined, no difference was found between obsession–compulsion and psychological resilience in terms of total score. However, there are relationships in subdimensions. Contamination subscore of VOCI and social resources subscore of Resilience Scale for Adults were found to be higher than the others. Hoarding was higher in men, while self perception, structural style, and family cohesion were higher in women. Single participants
had higher obsession–compulsion scores, whereas married participants had higher self perception and family adjustment. It was concluded that as individuals’ age increased, their self perception and social competence increased. Relationships were also found in terms of both obsession–compulsion and psychological resilience with variables, such as the frequency of COVID 19 news and case follow up, the frequency of body screening for COVID 19 symptoms, the change in the frequency of cleaning, and the idea of getting psychological support. Conclusion: This research is significant when it comes to seeing the effect of a compulsive life event, such as an epidemic disease on obsessive and compulsive behaviors.


Original Article

Examining the Relationship between the Knowledge of Sexually Transmitted Diseases and Sexual Myths among University Students in Turkey

Turkish Title : Examining the Relationship between the Knowledge of Sexually Transmitted Diseases and Sexual Myths among University Students in Turkey

Balkanoglu Cuneyt,Erensoy Habib,Donmezler Suleyman,Berkol Tonguc Demir
JNBS, 2021, 8(1), p:54-61

DOI : 10.4103/jnbs.jnbs_38_20

Objective: The purpose of this study is to evaluate the level of knowledge among university students on sexually transmitted diseases (STDs) and to compare the level of knowledge of this sample on STDs and their sexual myths. Methods: The sociodemographic data of 200 university students studying at several universities in Turkey randomly selected between January and March 2019 were evaluated with the “Sociodemographic Questionnaire,” their knowledge of STDs with the Sexually Transmitted Diseases Knowledge Questionnaire (STDKQ), and their beliefs in sexual myths with the Sexual Myths Scale (SMS). Results: There was no difference between the STDKQ and the SMS in terms of demographic variables. However, differentiation was seen between the “sexual behavior,” which is one of the subscales of sexual myths, and STDs. The STDKQ scores revealed that individuals who were previously informed received higher scores than those who did not. The level of knowledge about STDs was higher in men than in women. Conclusion: The knowledge of STDs among university students and their beliefs in sexual myths were evaluated based on sociodemographic variables. According to the results, we obtained from our research to increase the level of knowledge about STDs, and for the healthy development of sexual behavior, formal education including sexual health issues should be provided, research should be done for each region in Turkey on this subject, and in line with the results, necessary information should be provided regarding sexual health.

Objective: The purpose of this study is to evaluate the level of knowledge among university students on sexually transmitted diseases (STDs) and to compare the level of knowledge of this sample on STDs and their sexual myths. Methods: The sociodemographic data of 200 university students studying at several universities in Turkey randomly selected between January and March 2019 were evaluated with the “Sociodemographic Questionnaire,” their knowledge of STDs with the Sexually Transmitted Diseases Knowledge Questionnaire (STDKQ), and their beliefs in sexual myths with the Sexual Myths Scale (SMS). Results: There was no difference between the STDKQ and the SMS in terms of demographic variables. However, differentiation was seen between the “sexual behavior,” which is one of the subscales of sexual myths, and STDs. The STDKQ scores revealed that individuals who were previously informed received higher scores than those who did not. The level of knowledge about STDs was higher in men than in women. Conclusion: The knowledge of STDs among university students and their beliefs in sexual myths were evaluated based on sociodemographic variables. According to the results, we obtained from our research to increase the level of knowledge about STDs, and for the healthy development of sexual behavior, formal education including sexual health issues should be provided, research should be done for each region in Turkey on this subject, and in line with the results, necessary information should be provided regarding sexual health.


Original Article

Evaluating of Solute Carrier Family 6 Member 4 Gene (SLC6A4) Promoter Polymorphisms with Escitalopram Plasma Levels for Precision Medicine in Major Depressive Disorder

Turkish Title : Evaluating of Solute Carrier Family 6 Member 4 Gene (SLC6A4) Promoter Polymorphisms with Escitalopram Plasma Levels for Precision Medicine in Major Depressive Disorder

Canbolat Fadime,Erinc Dilek Meltem Tasdemir,Sercan Canan,Evrensel Alper,Ulucan Korkut,Aydın Ahmet,Tarhan Kasif Nevzat
JNBS, 2021, 8(1), p:62-69

DOI : 10.4103/jnbs.jnbs_44_20

Aim and Objective: Escitalopram (SCT) shows an antidepressant effect due to its mechanism of increasing the serotonin level by inhibiting the serotonin transporter protein (5HTT). 5HTT is encoded by solute carrier family 6 member 4 gene (SLC6A4) in the brain. Recognition of SCT plasma level of patients and pharmacodynamics of individuals during SCT treatment will increase the expected response to the treatment and reduce the adverse effects. This study aims to determine the effect of SLC6A4 promoter long/ short polymorphism and the SCT plasma level of patients on the response to treatment during the SCT drug therapy. Materials and Methods: Blood and plasma samples of 30 major depressive patients using 20 mg SCT for 8 weeks between the ages of 18 and 65 were analyzed to determine SCT plasma level and SLC6A4 promoter polymorphism. The treatment response level was determined by using the Hamilton Depression Rating Scale at patient files. Results: SCT plasma level of the nine patients with LL polymorphism was found to be in the range of 13.40–63.36 ng/mL. For 13 patients with LS polymorphism, SCT plasma level was found to be in the range of 2.93–57.48 ng/mL. For eight patients with SS polymorphism, the SCT plasma level was found to be in the range of 0.95–49.32 ng/mL. Conclusion: When the association between SCT plasma level and response to the drug treatment was examined, we had significant results to show that SCT level affected the response to treatment, especially in the LS group, as well as the SLC6A4 promoter variation. This study may lead to a more profound understanding of rational drug therapy as well as to a careful application of pharmacogenetics in psychiatry.

Aim and Objective: Escitalopram (SCT) shows an antidepressant effect due to its mechanism of increasing the serotonin level by inhibiting the serotonin transporter protein (5HTT). 5HTT is encoded by solute carrier family 6 member 4 gene (SLC6A4) in the brain. Recognition of SCT plasma level of patients and pharmacodynamics of individuals during SCT treatment will increase the expected response to the treatment and reduce the adverse effects. This study aims to determine the effect of SLC6A4 promoter long/ short polymorphism and the SCT plasma level of patients on the response to treatment during the SCT drug therapy. Materials and Methods: Blood and plasma samples of 30 major depressive patients using 20 mg SCT for 8 weeks between the ages of 18 and 65 were analyzed to determine SCT plasma level and SLC6A4 promoter polymorphism. The treatment response level was determined by using the Hamilton Depression Rating Scale at patient files. Results: SCT plasma level of the nine patients with LL polymorphism was found to be in the range of 13.40–63.36 ng/mL. For 13 patients with LS polymorphism, SCT plasma level was found to be in the range of 2.93–57.48 ng/mL. For eight patients with SS polymorphism, the SCT plasma level was found to be in the range of 0.95–49.32 ng/mL. Conclusion: When the association between SCT plasma level and response to the drug treatment was examined, we had significant results to show that SCT level affected the response to treatment, especially in the LS group, as well as the SLC6A4 promoter variation. This study may lead to a more profound understanding of rational drug therapy as well as to a careful application of pharmacogenetics in psychiatry.


Original Article

Comparison of Job Satisfaction, Work–Life Quality, and Compassion Level between Psychologists and Psychological Counselors

Turkish Title : Comparison of Job Satisfaction, Work–Life Quality, and Compassion Level between Psychologists and Psychological Counselors

Tahincioglu Dilara,Donmezler Suleyman,Erensoy Habib,Berkol Tonguc Demir
JNBS, 2021, 8(1), p:70-77

DOI : 10.4103/jnbs.jnbs_43_20

Introduction: Various studies have been conducted in the literature on job satisfaction, work‑related quality of life, and compassion with different sample groups. Our aim is to compare psychologists and psychological counselors (PC) in terms of these variables. Methods: It consists of 60 participants; 41 women and 19 men, 30 psychologists and 30 PC, aged between 23 and 52 years, working in schools, clinics, hospitals, and other institutions. Participants filled out a sociodemographic information form and were subjected to the Minnesota job satisfaction scale, the work‑related quality of life scale, and the compassion scale. Ethical Aspect of the Study: This study was approved by the T.R. University of Üsküdar, Non‑Interventional Studies Ethics Committee. Results: It was determined that as the age of psychologists and PC increases, their level of disconnection decreases in terms of compassion (r = −0.264; P = 0.041); thus, their ability to create a rapport increases with age, their compassion fatigue decreases as the workplace changes (r = −0.256; P = 0.048), their job satisfaction decreases as the noise level in the workplace increases (r = −0.433; P = 0.001), their job satisfaction increases as the work‑related quality of
life increases (r = 0.373; P = 0.003), their humaneness increases as their professional satisfaction increases, and their level of indifference and conscious awareness decreases as their compassion fatigue increases. Conclusion: Compassion fatigue is considered to be more related to the traumatic burden of the work done, because as the frequency of workplace changes increases, compassion fatigue decreases. The findings indicate that psychologists and PCs not only need to have suitable working areas available for their work but also need to change their work fields from time to time. It can be argued that the job satisfaction and work‑related quality of life of psychologists and PCs working in private clinics are higher than those working in schools; moreover, the reason for the lower levels of burnouts may be due to the noise levels, as well as the workload at the workplace, other occupational groups, and the culture of the institution.

Introduction: Various studies have been conducted in the literature on job satisfaction, work‑related quality of life, and compassion with different sample groups. Our aim is to compare psychologists and psychological counselors (PC) in terms of these variables. Methods: It consists of 60 participants; 41 women and 19 men, 30 psychologists and 30 PC, aged between 23 and 52 years, working in schools, clinics, hospitals, and other institutions. Participants filled out a sociodemographic information form and were subjected to the Minnesota job satisfaction scale, the work‑related quality of life scale, and the compassion scale. Ethical Aspect of the Study: This study was approved by the T.R. University of Üsküdar, Non‑Interventional Studies Ethics Committee. Results: It was determined that as the age of psychologists and PC increases, their level of disconnection decreases in terms of compassion (r = −0.264; P = 0.041); thus, their ability to create a rapport increases with age, their compassion fatigue decreases as the workplace changes (r = −0.256; P = 0.048), their job satisfaction decreases as the noise level in the workplace increases (r = −0.433; P = 0.001), their job satisfaction increases as the work‑related quality of
life increases (r = 0.373; P = 0.003), their humaneness increases as their professional satisfaction increases, and their level of indifference and conscious awareness decreases as their compassion fatigue increases. Conclusion: Compassion fatigue is considered to be more related to the traumatic burden of the work done, because as the frequency of workplace changes increases, compassion fatigue decreases. The findings indicate that psychologists and PCs not only need to have suitable working areas available for their work but also need to change their work fields from time to time. It can be argued that the job satisfaction and work‑related quality of life of psychologists and PCs working in private clinics are higher than those working in schools; moreover, the reason for the lower levels of burnouts may be due to the noise levels, as well as the workload at the workplace, other occupational groups, and the culture of the institution.


Original Article

EVALUATION OF THE EFFECTS OF LACTATIONAL EXPOSURE TO HYOSCYAMINE FRACTION OF DATURA STRAMONIUM L. SEEDS ON LEARNING AND MEMORY IN WISTAR RATS (RATTUS NORVEGICUS)

Turkish Title : EVALUATION OF THE EFFECTS OF LACTATIONAL EXPOSURE TO HYOSCYAMINE FRACTION OF DATURA STRAMONIUM L. SEEDS ON LEARNING AND MEMORY IN WISTAR RATS (RATTUS NORVEGICUS)

Tela dris Abdu,Musa Sunday Abraham,Iliya Ibrahim Abdullahi,Nzalak James Oliver
JNBS, 2020, 7(3), p:106-114

DOI : 10.4103/jnbs.jnbs_17_20

The study was designed to determine whether lactational exposure to hyoscyamine fraction of Datura stramonium L. (D. stramonium) seeds affect the cognitive, spatial learning and memory functions of the hippocampus in Wistar rats at adulthood. Fresh seeds of D. stramonium L. were procured, macerated and fractionated using high-performance liquid chromatography (HPLC). Eight (8) Wistar rats weighed 150-250 grams of equal gender were used for the study. The rats were mated and divided into control and treatment groups. Equivalent body weight of normal saline and 400 mg/kgbwt of hyoscyamine fraction were orally administered to the breastfeeding rats respectively on lactational days (LD) 1-21. At adulthood, the rats were subjected to neurobehavioural tests using novel objects recognition (NORT) and Morris water maze (MWM) respectively. The data obtained were expressed as mean ± SEM, independent two samples t-test and General Linear Model (GLM) repeatedmeasures ANOVA with Fisher’s multiple comparisons post-hoc tests were used to show the mean differences using Minitab 17 (LLC., U.K.) statistical package software. P < 0.05 was considered statistically significant. A significant increase in the meantime of exploration between the groups (p = 0.049) was observed during the NORT. No statistically significant increase (p = 0.626) in the meantime to locate the escape platform between the groups during the MWM test. The CA1 region of the treated group showed mild nuclear hyperchromasia, cytoplasmic vacuolations and pyknosis. In conclusion, exposure to hyoscyamine fraction of D. stramonium L. seeds at lactation caused histologic changes in the CA1 region, loss in short-term memory but not spatial learning and memory functions of the hippocampus of Wistar rats at adulthood.

The study was designed to determine whether lactational exposure to hyoscyamine fraction of Datura stramonium L. (D. stramonium) seeds affect the cognitive, spatial learning and memory functions of the hippocampus in Wistar rats at adulthood. Fresh seeds of D. stramonium L. were procured, macerated and fractionated using high-performance liquid chromatography (HPLC). Eight (8) Wistar rats weighed 150-250 grams of equal gender were used for the study. The rats were mated and divided into control and treatment groups. Equivalent body weight of normal saline and 400 mg/kgbwt of hyoscyamine fraction were orally administered to the breastfeeding rats respectively on lactational days (LD) 1-21. At adulthood, the rats were subjected to neurobehavioural tests using novel objects recognition (NORT) and Morris water maze (MWM) respectively. The data obtained were expressed as mean ± SEM, independent two samples t-test and General Linear Model (GLM) repeatedmeasures ANOVA with Fisher’s multiple comparisons post-hoc tests were used to show the mean differences using Minitab 17 (LLC., U.K.) statistical package software. P < 0.05 was considered statistically significant. A significant increase in the meantime of exploration between the groups (p = 0.049) was observed during the NORT. No statistically significant increase (p = 0.626) in the meantime to locate the escape platform between the groups during the MWM test. The CA1 region of the treated group showed mild nuclear hyperchromasia, cytoplasmic vacuolations and pyknosis. In conclusion, exposure to hyoscyamine fraction of D. stramonium L. seeds at lactation caused histologic changes in the CA1 region, loss in short-term memory but not spatial learning and memory functions of the hippocampus of Wistar rats at adulthood.


Original Article

COMPUTATIONAL MODELLING OF TRANS-ZEATIN AS A NOVEL TARGET OF ADENOSINE A2A RECEPTOR: INSIGHTS INTO MOLECULAR INTERACTIONS

Turkish Title : COMPUTATIONAL MODELLING OF TRANS-ZEATIN AS A NOVEL TARGET OF ADENOSINE A2A RECEPTOR: INSIGHTS INTO MOLECULAR INTERACTIONS

Destan Ebru,Öz Pınar,Timucin Ahmet Can
JNBS, 2020, 7(3), p:115-124

DOI : 10.4103/jnbs.jnbs_19_20

Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that is involved in various physiological functions. Zeatin, a plant cytokinin and a derivative of adenine, is recently identified as new ligand of A2AR. However, the ligand-receptor interaction mechanism is not fully revealed. Here, we report a model structure of A2AR in complex with zeatin for the first time, to provide a better understanding of this interaction mechanism. A model structure of A2AR in complex with caffeine used as a positive control. As a result, zeatin displayed the ability to stay more stable at the binding pocket compared with caffeine and the residues involved in the interaction are identified. We propose that zeatin is indeed a novel and promising target for A2AR

Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that is involved in various physiological functions. Zeatin, a plant cytokinin and a derivative of adenine, is recently identified as new ligand of A2AR. However, the ligand-receptor interaction mechanism is not fully revealed. Here, we report a model structure of A2AR in complex with zeatin for the first time, to provide a better understanding of this interaction mechanism. A model structure of A2AR in complex with caffeine used as a positive control. As a result, zeatin displayed the ability to stay more stable at the binding pocket compared with caffeine and the residues involved in the interaction are identified. We propose that zeatin is indeed a novel and promising target for A2AR


Original Article

THE RELATIONSHIP BETWEEN THE VISUAL-SPATIAL PERCEPTIONS AND FACE RECOGNITION SKILLS IN PARENTS OF THE CHILDREN WITH AUTISM SPECTRUM DISORDER

Turkish Title : THE RELATIONSHIP BETWEEN THE VISUAL-SPATIAL PERCEPTIONS AND FACE RECOGNITION SKILLS IN PARENTS OF THE CHILDREN WITH AUTISM SPECTRUM DISORDER

Gokten Emel Sari,Uckun Burcu,Budak Ersin,Tufan Ali Evren
JNBS, 2020, 7(3), p:125-132

DOI : 10.4103/jnbs.jnbs_25_20

The aim of this study is to examine the correlation between the autism symptoms of children with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of the parents of these children. In the study, the parents of 30 children (30 mothers, 30 fathers) diagnosed with Intellectual Developmental Disorder and the parents of 30 children (30 mothers, 30 fathers) without any psychiatric disorder, totally 180 people, were assessed in order to compare the data of the parents of 30 children (30 mothers, 30 fathers) diagnosed with Autism Spectrum Disorder. Autism Behavior Checklist (ABC) was used in order to assess the symptoms of the children diagnosed with Autism Spectrum Disorder. Benton’s Judgment of Line Orientation Test (BJLO), Benton Facial Recognition Test (BFRT), and Symptom Checklist (SCL-90) were used in order to assess the parents in three groups. It was found that there was no correlation between the autism symptoms of the children diagnosed with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of their parents. The spatial perception skills of the fathers in the Autism Spectrum Disorder group were higher compared to the mothers in this group (p<0.001), it was found that the 14.4% (p=0.022) of the BFRT scores of the fathers in the Autism Spectrum Disorder and 11.8% (p=0.035) of the BFRT scores of the fathers in the Intellectual Developmental Disorder group were explained by the BJLO scores. It may be useful to focus on the gender, face recognition skill and the visual-spatial perception performance when researching the genetical aspects of the face processing disorder seen as consistent information in the Autism Spectrum Disorder phenotype

The aim of this study is to examine the correlation between the autism symptoms of children with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of the parents of these children. In the study, the parents of 30 children (30 mothers, 30 fathers) diagnosed with Intellectual Developmental Disorder and the parents of 30 children (30 mothers, 30 fathers) without any psychiatric disorder, totally 180 people, were assessed in order to compare the data of the parents of 30 children (30 mothers, 30 fathers) diagnosed with Autism Spectrum Disorder. Autism Behavior Checklist (ABC) was used in order to assess the symptoms of the children diagnosed with Autism Spectrum Disorder. Benton’s Judgment of Line Orientation Test (BJLO), Benton Facial Recognition Test (BFRT), and Symptom Checklist (SCL-90) were used in order to assess the parents in three groups. It was found that there was no correlation between the autism symptoms of the children diagnosed with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of their parents. The spatial perception skills of the fathers in the Autism Spectrum Disorder group were higher compared to the mothers in this group (p<0.001), it was found that the 14.4% (p=0.022) of the BFRT scores of the fathers in the Autism Spectrum Disorder and 11.8% (p=0.035) of the BFRT scores of the fathers in the Intellectual Developmental Disorder group were explained by the BJLO scores. It may be useful to focus on the gender, face recognition skill and the visual-spatial perception performance when researching the genetical aspects of the face processing disorder seen as consistent information in the Autism Spectrum Disorder phenotype


ISSN (Print) 2149-1909
ISSN (Online) 2148-4325

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