Septum pellucidum, which forms the medial wall of the lateral ventricles, consists of two laminates. Cavum septum pellucidum (CSP) is defined when there is a space between these laminae. In some MRI studies have shown a higher rate of large CSP in patients with schizophrenia than in normal subjects. Looking at the literature on psychiatric disorders, CSP has been shown to be most associated with schizophrenia. Large CSP supports the neurodevelopmental model, which is one of the etiological explanations of schizophrenia. In our study, two patients with a diagnosis of CSP are mentioned. One of our patients is a first episode of schizophrenia, and the other one chronic schizophrenia patient with a history of multi-drug resistance. The first episode of schizophrenia is consistent with the information available in the literature in terms of the severity of symptoms, weak-response to treatment, and insufficiency of neuropsychological tests. The apparent deficit of the chronic schizophrenia patient suggests that CSP has a neurodevelopmental model in the etiology of schizophrenia, as well as the duration of the disease and non-compliance with treatment. There is no study in the literature comparing the response to treatment with large CSP in schizophrenia. It is thought that investigation of response to treatment in future studies is important for demonstrating the effects of neurodevelopmental model on the treatment of psychiatric disorders.

Varenicline emerged as an efficient smoking cessation medication. However, little is known about its association with seizures. Here, we report a case of a young male who suffered a seizure on the day of the last dose of the suggested drug regimen. We argue that the Varenicline seizure was a result of withdrawal rather than a side effect. We therefore discuss several clinical, legal and legislative implications toward the drug prescription and dispensing.

Sydenham’s chorea is a Immune-mediated disorder of the central nervous system characterized by sudden, involuntary, arrhythmic, choreic, and purposeless movements. It is a nonsuppurative sequel of group A streptococcal tonsillo pharyngitis, which is known to be a common cause of chorea. According to the 1992 modified Jones criteria, acute rheumatic fever is a major criterion and is sufficient evidence on which to base a diagnosis. In this case report, an 11-year-old girl was admitted to the child and adolescent psychiatry clinic with involuntary contractions and emotional changes and was diagnosed with Sydenham's chorea with neurological consultation and his symptoms regressed with haloperidol and valproate therapy. Theaim of thestudy is to show the similarities in terms of mood and tic disorders in the differential diagnosis and treatment of sydenham chorea case who applied to child psychiatry clinic, can be an auxiliary source in a similar case.