Aims and Objectives: In this study, obsessions and compulsions observed during the epidemic period were investigated in terms of psychological resilience. Materials and Methods: The research was conducted on a voluntary basis with 208 people (51.4% women, 48.6% men) who were exposed to the COVID 19 epidemic. Participants were given a Sociodemographic Information Form including questions about COVID 19, Vancouver Obsession–Compulsion Inventory (VOCI), and Adult Psychological Resilience Scale. Data were analyzed with Statistical Package Program for Social Science 21.0 program. Results: When the findings were examined, no difference was found between obsession–compulsion and psychological resilience in terms of total score. However, there are relationships in subdimensions. Contamination subscore of VOCI and social resources subscore of Resilience Scale for Adults were found to be higher than the others. Hoarding was higher in men, while self perception, structural style, and family cohesion were higher in women. Single participants
had higher obsession–compulsion scores, whereas married participants had higher self perception and family adjustment. It was concluded that as individuals’ age increased, their self perception and social competence increased. Relationships were also found in terms of both obsession–compulsion and psychological resilience with variables, such as the frequency of COVID 19 news and case follow up, the frequency of body screening for COVID 19 symptoms, the change in the frequency of cleaning, and the idea of getting psychological support. Conclusion: This research is significant when it comes to seeing the effect of a compulsive life event, such as an epidemic disease on obsessive and compulsive behaviors.

Objective: The purpose of this study is to evaluate the level of knowledge among university students on sexually transmitted diseases (STDs) and to compare the level of knowledge of this sample on STDs and their sexual myths. Methods: The sociodemographic data of 200 university students studying at several universities in Turkey randomly selected between January and March 2019 were evaluated with the “Sociodemographic Questionnaire,” their knowledge of STDs with the Sexually Transmitted Diseases Knowledge Questionnaire (STDKQ), and their beliefs in sexual myths with the Sexual Myths Scale (SMS). Results: There was no difference between the STDKQ and the SMS in terms of demographic variables. However, differentiation was seen between the “sexual behavior,” which is one of the subscales of sexual myths, and STDs. The STDKQ scores revealed that individuals who were previously informed received higher scores than those who did not. The level of knowledge about STDs was higher in men than in women. Conclusion: The knowledge of STDs among university students and their beliefs in sexual myths were evaluated based on sociodemographic variables. According to the results, we obtained from our research to increase the level of knowledge about STDs, and for the healthy development of sexual behavior, formal education including sexual health issues should be provided, research should be done for each region in Turkey on this subject, and in line with the results, necessary information should be provided regarding sexual health.

Aim and Objective: Escitalopram (SCT) shows an antidepressant effect due to its mechanism of increasing the serotonin level by inhibiting the serotonin transporter protein (5HTT). 5HTT is encoded by solute carrier family 6 member 4 gene (SLC6A4) in the brain. Recognition of SCT plasma level of patients and pharmacodynamics of individuals during SCT treatment will increase the expected response to the treatment and reduce the adverse effects. This study aims to determine the effect of SLC6A4 promoter long/ short polymorphism and the SCT plasma level of patients on the response to treatment during the SCT drug therapy. Materials and Methods: Blood and plasma samples of 30 major depressive patients using 20 mg SCT for 8 weeks between the ages of 18 and 65 were analyzed to determine SCT plasma level and SLC6A4 promoter polymorphism. The treatment response level was determined by using the Hamilton Depression Rating Scale at patient files. Results: SCT plasma level of the nine patients with LL polymorphism was found to be in the range of 13.40–63.36 ng/mL. For 13 patients with LS polymorphism, SCT plasma level was found to be in the range of 2.93–57.48 ng/mL. For eight patients with SS polymorphism, the SCT plasma level was found to be in the range of 0.95–49.32 ng/mL. Conclusion: When the association between SCT plasma level and response to the drug treatment was examined, we had significant results to show that SCT level affected the response to treatment, especially in the LS group, as well as the SLC6A4 promoter variation. This study may lead to a more profound understanding of rational drug therapy as well as to a careful application of pharmacogenetics in psychiatry.

Introduction: Various studies have been conducted in the literature on job satisfaction, work‑related quality of life, and compassion with different sample groups. Our aim is to compare psychologists and psychological counselors (PC) in terms of these variables. Methods: It consists of 60 participants; 41 women and 19 men, 30 psychologists and 30 PC, aged between 23 and 52 years, working in schools, clinics, hospitals, and other institutions. Participants filled out a sociodemographic information form and were subjected to the Minnesota job satisfaction scale, the work‑related quality of life scale, and the compassion scale. Ethical Aspect of the Study: This study was approved by the T.R. University of Üsküdar, Non‑Interventional Studies Ethics Committee. Results: It was determined that as the age of psychologists and PC increases, their level of disconnection decreases in terms of compassion (r = −0.264; P = 0.041); thus, their ability to create a rapport increases with age, their compassion fatigue decreases as the workplace changes (r = −0.256; P = 0.048), their job satisfaction decreases as the noise level in the workplace increases (r = −0.433; P = 0.001), their job satisfaction increases as the work‑related quality of
life increases (r = 0.373; P = 0.003), their humaneness increases as their professional satisfaction increases, and their level of indifference and conscious awareness decreases as their compassion fatigue increases. Conclusion: Compassion fatigue is considered to be more related to the traumatic burden of the work done, because as the frequency of workplace changes increases, compassion fatigue decreases. The findings indicate that psychologists and PCs not only need to have suitable working areas available for their work but also need to change their work fields from time to time. It can be argued that the job satisfaction and work‑related quality of life of psychologists and PCs working in private clinics are higher than those working in schools; moreover, the reason for the lower levels of burnouts may be due to the noise levels, as well as the workload at the workplace, other occupational groups, and the culture of the institution.

Major depression disorder in its nature and antidepressants as side effects may cause people to have sexual dysfunction. In the literature, it has been shown in a few examples that it may be beneficial for sexual dysfunction to switch drugs from a selective serotonin reuptake inhibitor to vortioxetine. Vortioxetine is an antagonist for 5‐HT3 and 5‐HT7, a partial agonist for HT1B and agonist for 5‐ HT1A and has been known for its low level of sexual dysfunctionality. There is a case showing that vortioxetine with high doses might cause sexual impairment and dose reduction might be a treatment option for this side effect. In this case, vortioxetine dose reduction and sexual improvement were simultaneous. Although the sensory exercises might also help the treatment of sexual dysfunction, it should not be ignored that vortioxetine may cause dose‐dependent sexual side effects.

Coronavirus disease 2019 (COVID-19) has become a pandemic with 8.708.000 confirmed cases and, 461.715 death in the world until 21 June 2020. The SARS-CoV-2 virus which is an enveloped and single-stranded RNA virus belonging to Coronaviridea family causes multiple organ systems diseases such as respiratory, gastrointestinal, hepatic and neurological tracts in humans and, animals. With the rapid and global spread of COVID-19, the scientific authorities have developed treatment algorithms for COVID-19. Besides the supportive care, chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, tocilizumab, azithromycin, vitamin C, Convalescent plasma therapy are frequently used off-label to treat COVID-19. For severe COVID-19 cases, US Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) Remdesivir, which is the first drug to earn the title. COVID-19 treatment may cause many side effects and drug interactions. Psychiatric diseases are also chronic diseases and psychiatric drugs may have severe interactions with COVID-19 medications. Drug interactions with psychiatric medication and neuropsychiatric side effects should be considered within the action mechanism of COVID-19 treatments. Thus, In this review, we aimed to elucidate the interactions of COVID-19 medications with the antidepressants, antipsychotics and, the other psychotropic drugs that have been frequently used in psychiatric diseases. Chloroquine, hydroxychloroquine, azithromycin, ribavirin, lopinavir/ritonavir have interactions with psychiatric medications such as antidepressants, antipsychotics, anticonvulsants and, anxiolytics in terms of QTc interval prolongation, hepatotoxicity, myelosuppression, increased or decreased concentration of medications. Remdesivir has lower interactions with most of the psychiatric drugs except St John’s Wort and some anticonvulsants. However, favipiravir is considered as the COVID-19 medication which has lower interaction and side effects in combination with psychiatric medication. The use of tocilizumab is also safe with most of the psychiatric drugs and has a positive effect on depressive symptoms, although there is a risk of hepatotoxicity.

The study was designed to determine whether lactational exposure to hyoscyamine fraction of Datura stramonium L. (D. stramonium) seeds affect the cognitive, spatial learning and memory functions of the hippocampus in Wistar rats at adulthood. Fresh seeds of D. stramonium L. were procured, macerated and fractionated using high-performance liquid chromatography (HPLC). Eight (8) Wistar rats weighed 150-250 grams of equal gender were used for the study. The rats were mated and divided into control and treatment groups. Equivalent body weight of normal saline and 400 mg/kgbwt of hyoscyamine fraction were orally administered to the breastfeeding rats respectively on lactational days (LD) 1-21. At adulthood, the rats were subjected to neurobehavioural tests using novel objects recognition (NORT) and Morris water maze (MWM) respectively. The data obtained were expressed as mean ± SEM, independent two samples t-test and General Linear Model (GLM) repeatedmeasures ANOVA with Fisher’s multiple comparisons post-hoc tests were used to show the mean differences using Minitab 17 (LLC., U.K.) statistical package software. P < 0.05 was considered statistically significant. A significant increase in the meantime of exploration between the groups (p = 0.049) was observed during the NORT. No statistically significant increase (p = 0.626) in the meantime to locate the escape platform between the groups during the MWM test. The CA1 region of the treated group showed mild nuclear hyperchromasia, cytoplasmic vacuolations and pyknosis. In conclusion, exposure to hyoscyamine fraction of D. stramonium L. seeds at lactation caused histologic changes in the CA1 region, loss in short-term memory but not spatial learning and memory functions of the hippocampus of Wistar rats at adulthood.

Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that is involved in various physiological functions. Zeatin, a plant cytokinin and a derivative of adenine, is recently identified as new ligand of A2AR. However, the ligand-receptor interaction mechanism is not fully revealed. Here, we report a model structure of A2AR in complex with zeatin for the first time, to provide a better understanding of this interaction mechanism. A model structure of A2AR in complex with caffeine used as a positive control. As a result, zeatin displayed the ability to stay more stable at the binding pocket compared with caffeine and the residues involved in the interaction are identified. We propose that zeatin is indeed a novel and promising target for A2AR

The aim of this study is to examine the correlation between the autism symptoms of children with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of the parents of these children. In the study, the parents of 30 children (30 mothers, 30 fathers) diagnosed with Intellectual Developmental Disorder and the parents of 30 children (30 mothers, 30 fathers) without any psychiatric disorder, totally 180 people, were assessed in order to compare the data of the parents of 30 children (30 mothers, 30 fathers) diagnosed with Autism Spectrum Disorder. Autism Behavior Checklist (ABC) was used in order to assess the symptoms of the children diagnosed with Autism Spectrum Disorder. Benton’s Judgment of Line Orientation Test (BJLO), Benton Facial Recognition Test (BFRT), and Symptom Checklist (SCL-90) were used in order to assess the parents in three groups. It was found that there was no correlation between the autism symptoms of the children diagnosed with Autism Spectrum Disorder and the visual-spatial perceptions and face recognition skills of their parents. The spatial perception skills of the fathers in the Autism Spectrum Disorder group were higher compared to the mothers in this group (p<0.001), it was found that the 14.4% (p=0.022) of the BFRT scores of the fathers in the Autism Spectrum Disorder and 11.8% (p=0.035) of the BFRT scores of the fathers in the Intellectual Developmental Disorder group were explained by the BJLO scores. It may be useful to focus on the gender, face recognition skill and the visual-spatial perception performance when researching the genetical aspects of the face processing disorder seen as consistent information in the Autism Spectrum Disorder phenotype

The anxiety level of an athlete is important. The serotonin transporter protein is encoded by the SLC6A4 gene. Serotonin is one of the most important members of anxiety metabolism. Serotonin transporter protein plays a role in bringing serotonin back from the synaptic space to the presynaptic neuron. We aimed to determine the genotype and allele distributions of the SLC6A4 promoter L/S polymorphism in football players and compare it with the control group. For this purpose, 20 football players participated in our study. Genotyping was performed by PCR after DNAs were isolated from buccal epithelial cells. When we examined the genotype distributions, the LL, LS and SS were found as 4 (20%), 8 (40%) and 8 (40%), respectively. In the control group, the same genotype number and percentages were determined as 10 (23%), 25 (57%) and 9 (20%), respectively. In terms of genotype distribution, no statistically significant significance was found between the two groups (p = 0.2493). When allelic distributions were examined in the athlete group, the L allele was counted as 16 (40%) and the S allele as 24 (60%). In the control group, the L allele 45 (51%) and the S allele were counted as 43 (49%). When the two groups were compared statistically in terms of allelic distribution, no statistically significant difference was found (p = 0.2423). As a result, LS and SS genotype were co-dominant and at the same time higher than LL genotype. At the same time, when we compared the S allele with the L allele, it was found that the S allele was more in percentage. Studies have found that the S allele is associated with anxiety. Sports psychologist can support athletes with S allele who are prone to anxiety problems. This is the first study to report that S allele is more common than L allele in Turkish football players.