Major depression disorder in its nature and antidepressants as side effects may cause people to have sexual dysfunction. In the literature, it has been shown in a few examples that it may be beneficial for sexual dysfunction to switch drugs from a selective serotonin reuptake inhibitor to vortioxetine. Vortioxetine is an antagonist for 5‐HT3 and 5‐HT7, a partial agonist for HT1B and agonist for 5‐ HT1A and has been known for its low level of sexual dysfunctionality. There is a case showing that vortioxetine with high doses might cause sexual impairment and dose reduction might be a treatment option for this side effect. In this case, vortioxetine dose reduction and sexual improvement were simultaneous. Although the sensory exercises might also help the treatment of sexual dysfunction, it should not be ignored that vortioxetine may cause dose‐dependent sexual side effects.