Aim: Few studies have investigated the effect of tic disorder (TD) co-occurring with obsessive-compulsive disorder (OCD) on smoking, alcohol use disorders (AUD) and substance use disorders (SUD). The present study aimed to investigate whether the presence of TD in adults with OCD is associated with differences in AUD/SUD, smoking, and adult-life variables including education, unemployment, marital status, and suicide attempts. Materials and Methods: In this cross-sectional observational study, we examined 559 adults with OCD, with or without TD, in terms of smoking, alcohol and substance use disorders (AUD/SUD) and adult-life variables including education, unemployment, marital status and suicide attempts (SA). Results: Fifty-four patients (9.66%) had current or past TD. Individuals with and without TD had similar prevalence of AUD/SUD and smoking and similar severity of OCD, anxiety and depressive symptoms. OCD+TD group was characterized by earlier OCD onset, male predominance, and low marriage prevalence. Educational attainment, unemployment rate and history of SA did not show any difference. Conclusion: TD accompanying OCD in adults does not worsen OCD severity, predisposition to harmful substances, educational attainment, unemployment rate or history of SA, although it appears to influence marital status.